N-BENZYLOXYCARBONYL-L-GLUTAMIC ACID ALPHA-BENZYL ESTER

N-BENZYLOXYCARBONYL-L-GLUTAMIC ACID ALPHA-BENZYL ESTER - Names and Identifiers

Name	Z-Glu-OBzl
Synonyms	Z-Glu-OBzl Z-L-GLU-OBZL Z-GLUTAMIC ACID-OBZL CBZ-L-GLUTAMIC ACID 2-BENZYL ESTER Cbz-L-Glutamic acid 1-benzyl ester N-Cbz-glutamic acid α-benzyl ester Z-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-ALPHA-CBZ-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-BENZYLOXYCARBONYL-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-ALPHA-CARBOBENZOXY-L-GLUTAMIC ACID ALPHA-BENZYL ESTER N-ALPHA-BENZYLOXYCARBONYL-L-GLUTAMIC-ACID-ALPHA-BENZYL ESTER 5-(benzyloxy)-4-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name) (4S)-5-(benzyloxy)-4-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name)
CAS	3705-42-8
EINECS	2017-001-1
InChI	InChI=1/C20H21NO6/c22-18(23)12-11-17(19(24)26-13-15-7-3-1-4-8-15)21-20(25)27-14-16-9-5-2-6-10-16/h1-10,17H,11-14H2,(H,21,25)(H,22,23)/t17-/m0/s1

N-BENZYLOXYCARBONYL-L-GLUTAMIC ACID ALPHA-BENZYL ESTER - Physico-chemical Properties

Molecular Formula	C20H21NO6
Molar Mass	371.38
Density	1.268±0.06 g/cm3(Predicted)
Melting Point	92-93?C
Boling Point	594.3±50.0 °C(Predicted)
Flash Point	313.2°C
Water Solubility	Soluble in methanol, dimethyl sulfoxide. Slightly soluble in water.
Solubility	Soluble in Methanol
Vapor Presure	5.72E-15mmHg at 25°C
Appearance	Crystalline powder
Color	White
pKa	4.47±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.575
MDL	MFCD00077013

N-BENZYLOXYCARBONYL-L-GLUTAMIC ACID ALPHA-BENZYL ESTER - Introduction

Z-Glu-OBzl(Z-Glu-OBzl) is an organic compound commonly used as a protecting group for amino acids. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Molecular formula: C17H17NO4
-Molecular weight: 303.32g/mol
-Appearance: White crystalline powder
-Melting Point: 84-85°C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dimethylformamide
- Cbz protecting group can be removed by palladium hydride catalyst under acidic conditions

Use:
- Z-Glu-OBzl is a protecting group of glutamic acid (Glu), which can be used in the synthesis of amino acid derivatives, polypeptides and proteins.
-As a protecting group for amino acids in synthetic organic compounds, it can protect the amine group of glutamic acid, prevent it from being affected by non-specific reactions, and facilitate removal when needed.

Preparation Method:
-The preparation of Z-Glu-OBzl usually includes a multi-step process and involves a series of chemical reactions. One of the common methods is to first protect the carboxyl group of glutamic acid as t-butoxycarbonyl ester (Boc) and then protect the amino group as Cbz. Finally, the desired product Z-Glu-OBzl is formed by reaction with benzyl chloroformate.

Safety Information:
- Z-Glu-OBzl should be treated as irritating compounds and avoid direct contact with skin and eyes.
-When used in the laboratory, correct safety procedures must be followed, including wearing protective glasses, gloves and laboratory coats.
-Inhalation or ingestion of the compound should be avoided and fire and explosion prevention measures should be taken during storage.
-The compound should be placed in a well-ventilated environment during processing, and waste should be properly disposed of in accordance with local regulations.

Last Update：2024-04-10 22:29:15